The eighteenth century is usually regarded as the period in which confession building processes, triggered both by the Greek Patriarchal Church and by Rome, resulted in an increasing estrangement between Greek and Latin Christianity. According to this historical narrative, the normative discourses on confessional identity and the provisions issued from above were to be effectively conveyed and transposed locally. This research project aims to shed fresh light on the confessionalization processes in action since the middle of the 18th century. Based on the documents stored in the Historical archive of Propaganda Fide in Rome and other primary sources, the project intends to investigate the developments in Greek-Latin relationships across the Mediterranean during this transitional period. Through a multi-local analysis, which spans from the Greek-rite settlements in Italy to the Greek East, an attempt will be made to interpret the confessionalization processes as a multifarious phenomenon resulting from the interaction between normative changes and local practices.